Jjkk 048, Potent And Selective Magl Inhibitor, Each

Details:

Jjkk 048 is a potent and selective monoacylglycerol lipase (magl) inhibitor (ic50 = 0.4 Nm). Exhibits >13,000 and ∽630-fold selectivity for magl over faah and abhd6, respectively. Increases brain levels of 2-arachidonoylglycerol (2-ag) levels in mice in vivo. Promotes analgesia in pain models.