Jnj 47965567, Potent And Selective P2x7 Antagonist; Brain Penetrant, Each

Details:

Jnj 47965567 is a potent and selective p2x7 antagonist (pic50 values are 8.3, 7.5 And 7.2 For human, mouse and rat receptors respectively). Selective over a panel of 50 other receptors, ion channels and transporters. Reduces bzatp -induced il-1β release from monocytes in vitro and from rat brain in vivo. Attenuates amphetamine -induced hyperactivity in rats. Brain penetrant.