M8 B Hydrochloride, Potent And Selective Trpm8 Channel Blocker, Each

Details:

M8 b hydrochloride is a potent and selective trpm8 channel blocker. Blocks cold- and icilin -induced trpm8 activation in vitro (ic50 values are 7.8 And 26.9 Nm respectively). Exhibits no effect at other trp channels (ic50 > 20 μm). Reduces body temperature in vivo.