ml 240, Atp-Competitive Inhibitor Of P97 Atpase, Each

Details:

Ml 240 is an atp-competitive inhibitor of p97 atpase (vcp, ic50 = 110 nm). Exhibits antiproliferative activity in nci-60 cancer cell lines and rapidly induces executioner caspases 3 and 7 in multiple colon cancer cells. Promotes accumulation of lc3-ii and impairs autophagosome maturation. Also impairs the endoplasmic-reticulum-associated degradation (erad) pathway.