ml 297, Selective Kir3.1/3.2 (Girk1/2) Channel Activator, Each

Details:

Ml 297 is a selective kir3.1/3.2 (Girk1/2) channel activator (ic50 values are 160, 887 and 914 nm for girk1/2, girk1/4 and girk1/3 respectively). Exhibits no effect on girk2, girk2/3, kir2.1 And kv7.4 Channels, and has minimal effect on a panel of other ion channels, receptors and transporters. Prevents ptz -induced epileptic seizures in mice. Brain penetrant.