Mrt 67307 Dihydrochloride, Salt Inducible Kinase (Sik) Inhibitor, Each

Details:

Mrt 67307 dihydrochloride is a salt inducible kinase (sik) inhibitor (ic50 values are 67, 250 and 430 nm for sik2, sik1 and sik3 respectively). Also inhibits tbk1, mark1-4, ikkε and nuak1 (ic50 values are 19, 27-52, 160 and 230 nm respectively). Has no effect on ikkα or ikkβ. Induces il-10 secretion and inhibits tnf-α and il-6 secretion in bacterial lps-stimulated macrophages. Also enhances il-1-induced activation of nfκb-dependent gene transcription in mouse embryonic fibroblast (mef) cells. Inhibits autophagy.