Pmx 53, Potent C5a Receptor Antagonist, Each

Details:

Pmx 53 is a potent c5a receptor antagonist (ic50 = 20 nm). Also mrgx2 agonist. Stimulates mrgx2-mediated mast cell degranulation. Also inhibits c5a-induced hypernociception in rats, inhibits lung metastasis in a mouse breast cancer model and reduces atherosclerotic lesions in a mouse model of atherosclerosis. Negative control also available.