Pregnenolone Sulfate Sodium Salt, Nmda Potentiator; Also Gabaa Inhibitor And Trpm3 Activator, Each

Details:

Pregnenolone sulfate sodium salt is a highly potent neurosteroid with multiple actions. Enhances intracellular ca2 upon nmda receptor-mediated synaptic activity (ec50 ∽ 2 pm) and potentiates nmda responses. Inhibitor at gabaa receptors (ic50 values are 0.4 To >300 μm, depending on specific subunit conformation). Activates creb phosphorylation, augments ltp and cognitive behavior in rat memory models. Also activates trpm3 channels.