Ptc 209, Bmi-1 Inhibitor; Antitumor, Each

Details:

Ptc 209 is a bmi-1 inhibitor (ic50 ∽ 0.5 μM); irreversibly impairs colorectal cancer-initiating cell (cic) growth. Reduces tumor growth in cic xenograft assays and results in reduced potential of colorectal cancer cells to initiate tumors in vivo.