R 268712, Potent And Selective Inhibitor Of Tgf-ΒRi, Each

Details:

R 268712 is a potent and selective inhibitor of the tgf-β type i receptor/alk5 (ic50 = 2.5 Nm). Exhibits ∽5000-fold selectivity over p38 mapk. Suppresses development of renal fibrosis in a unilateral ureteral obstruction model. Also reduces proteinuria, glomerulosclerosis and improves renal function in an anti-thy1 glomerulonephritis model. Orally bioavailable.