Sgi 1027, Dna Methyltransferase Inhibitor, Each

Details:

Sgi 1027 is a dna methyltransferase inhibitor. Inhibits the mammalian dna methyltransferases dnmt3b, dnmt3a and dnmt1 (ic50 values are 7.5, 8 And 12.5 μM with poly(dl-dc) as the substrate). Reactivates silenced tumor suppressor genes by reducing cpg island hypermethylation.