T 5601640, Selective Limk2 Inhibitor; Antitumor, Each

Details:

T 5601640 is a selective lim kinase 2 (limk2) inhibitor; inhibits cofilin phosphorylation in cells that overexpress limk2 but not limk1. Attenuates the growth of several cancer cell lines. Reduces phospho-cofilin levels and panc-1 tumor size in a mouse xenograft model.