Tc-S 7006, Potent And Selective Tpl2 (Cot; Map3k8) Inhibitor, Each

Details:

Tc-s 7006 is a potent and selective tpl2 (cot; map3k8) inhibitor (ic50 = 50 nm). Selective for tpl2 over mek, p38, src, mk2, pkc and egfr. Inhibits lps-induced tnf-α secretion from monocytes and attenuates acute myeloid leukemia (aml) cell proliferation in vitro. Also reduces cytolytic activity of human cd8 cytotoxic t lymphocytes. Cell permeable.