Vo-Ohpic, Potent Pten Inhibitor, Each

Details:

Vo-ohpic is a potent inhibitor of pten (phosphatase and tensin homolog) (ic50 = 35 nm). Displays selectivity for pten over cysteine-based phosphatases such as sopb, mtm, ptpβ and sac (ic50 values are 588 nm, 4.03, 57.5 And >10 μm respectively). Increases pip2 and pip3 levels; also increases akt translocation in nih/3t3 fibroblasts. Blocks the immunosuppressant activity of ido-activated tregs. Promotes antitumor inflammatory response in combination with immunotherapy and enhances anticancer chemotherapy in tumor-bearing mice.