Wh-4-023, Potent And Selective Lck And Src Inhibitor; Also Inhibits Sik, Each

Details:

Wh-4-023 is a potent and selective lck and src inhibitor (ic50 values are 2 and 6 nm respectively). Exhibits >300-fold selectivity against p38α and kdr. Also potently inhibits sik (ic50 values are 10, 22 and 60 nm for sik 1, 2 and 3 respectively) and displays selectivity over a range of closely related kinases. Supports self-renewal of naive hescs in combination with pd 0325901, chir 99021 and sb 590885 .