Tyr-(D-Dab4,Arg5,D-Trp8)-Cyclo ,Each

Details:

Tyr-(d-dab4,arg5,d-trp8)-cyclo-soma, 1mg high affinity ligand for all five somatostain receptors (sst1-sst5). In att-20 mouse anterior pituitary tumor cells which mainly express sst2 and sst5 receptors the binding affinity of this somatostatin analog was found to be higher than that of somatostatin-14 (h-1490) and octreotide (h-5972). In a model of epileptogenesis, however, ke 108 did not exhibit antiepileptic activity sug gesting that the high potency and efficacy of a synthetic ligand to all known somatostatin receptors may not reproduce entirely the effects of the natural ligand. Cas: 496849-46-8 c67h85n15o11 fw: 1276.51. Synonym: ke 108