Vasp Mouse, Unlabeled, Clone: 43, Bd, Mouse Monoclonal Antibody, Each

Details:

Vasodilator-stimulated phosphoprotein (vasp), a substrate for camp- and cgmp-dependent kinases, is associated with actin filaments, focal adhesions, and dynamic membrane regions. Vasp is composed of several distinct domains: a central l-proline-rich domain contains a gppppp motif as a single copy and as a three-fold tandem repeat, as well as three conserved phosphorylation sites for cyclic nucleotide-dependent protein kinases (ser157, ser239, and thr278). A c-terminal domain contains a repetitive mixed-charge cluster which is predicted to form an α-helix. The c-terminal domain appears to be responsible for anchoring at focal adhesion sites. Vasp has been shown to be a ligand for profilins. Profilins bind to the poly-l-proline motifs of vasp and it is postulated that these two molecules act in concert to convey signal transduction to actin filament formation.Immunofluorescence, immunoprecipitation, western blotting