Vkorc1 Rabbit Anti-Human, Polyclonal Antibody, Abnova, Rabbit Polyclonal Antibody Raised Against Recombinant Vkorc1, Each

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Vitamin k is essential for blood clotting but must be enzymatically activated. This enzymatically activated form of vitamin k is a reduced form required for the carboxylation of glutamic acid residues in some blood-clotting proteins. The product of this gene encodes the enzyme that is responsible for reducing vitamin k 2,3-epoxide to the enzymatically activated form. Fatal bleeding can be caused by vitamin k deficiency and by the vitamin k antagonist warfarin, and it is the product of this gene that is sensitive to warfarin. In humans, mutations in this gene can be associated with deficiencies in vitamin-k-dependent clotting factors and, in humans and rats, with warfarin resistance. Two pseudogenes have been identified on chromosome 1 and the x chromosome. Two alternatively spliced transcripts encoding different isoforms have been described. [Provided by refseqsequence: ardrdyralcdvgtaiscsrvfssrw